Issue 26, 2015

Preparation of upper critical solution temperature (UCST) responsive diblock copolymers bearing pendant ureido groups and their micelle formation behavior in water

Abstract

Poly(2-ureidoethyl methacrylate) (PUEM) was prepared via reversible addition–fragmentation chain transfer (RAFT) controlled radical polymerization and a post-modification reaction. PUEM shows upper critical solution temperature (UCST) behavior in aqueous solution. Although PUEM can dissolve in water above the UCST, it cannot dissolve in water below the UCST. Diblock copolymers (MmUn) composed of a biocompatible hydrophilic poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) block and a PUEM block with different compositions were prepared via RAFT radical polymerization and a post-modification reaction. “M” and “U” represent PMPC and PUEM blocks, respectively, and the subscripts represent the degree of polymerization of each block. M95U149 and M20U163 formed polymer micelles comprising a PUEM core and a PMPC shell below the critical aggregation temperature (Tc) in aqueous solution. Polymer micelles were formed from M20U163 below 32 °C, which can incorporate guest molecules into the core.

Graphical abstract: Preparation of upper critical solution temperature (UCST) responsive diblock copolymers bearing pendant ureido groups and their micelle formation behavior in water

Supplementary files

Article information

Article type
Paper
Submitted
01 Mar 2015
Accepted
07 May 2015
First published
07 May 2015

Soft Matter, 2015,11, 5204-5213

Author version available

Preparation of upper critical solution temperature (UCST) responsive diblock copolymers bearing pendant ureido groups and their micelle formation behavior in water

A. Fujihara, N. Shimada, A. Maruyama, K. Ishihara, K. Nakai and S. Yusa, Soft Matter, 2015, 11, 5204 DOI: 10.1039/C5SM00499C

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