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Issue 19, 2015
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Helical alignment inversion of microtubules in accordance with a structural change in their lattice

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Abstract

Giant helical (oriented chiral nematic) alignments of microtubules of nanometer to centimeter lengths are known to form over a temperature gradient during anisotropic spiral propagation via tubulin dimer addition in a capillary cell. Such helical alignments may be modified by the addition of either paclitaxel or dimethyl sulfoxide, which induces a lattice (helical) structural change in the microtubule itself. In this study, we found that the lattice structural change of microtubules brings about inversion of microtubule alignments in the helical ordering. Based on microscopy and scattering data, a mechanism for the helical ordering of microtubules is discussed in relation to their lattice (helical) structure.

Graphical abstract: Helical alignment inversion of microtubules in accordance with a structural change in their lattice

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Supplementary files

Article information


Submitted
28 Feb 2015
Accepted
06 Apr 2015
First published
07 Apr 2015

Soft Matter, 2015,11, 3869-3874
Article type
Paper
Author version available

Helical alignment inversion of microtubules in accordance with a structural change in their lattice

K. Shikinaka, S. Mori, K. Shigehara and H. Masunaga, Soft Matter, 2015, 11, 3869
DOI: 10.1039/C5SM00488H

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