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Issue 27, 2014
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Wrapping/unwrapping transition of double-stranded DNA in DNA–nanosphere complexes induced by multivalent anions

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Abstract

Wrapping and unwrapping behaviors of double-stranded DNA around a positively charged nanosphere in solution are studied by using the coarse-grained molecular dynamics (CGMD) simulation method. When monovalent, divalent and trivalent anions are added to the DNA–nanosphere complex solution, double-stranded DNA binds with a nanosphere owing to strong electrostatic attraction. However, when tetravalent anions are added to the DNA–nanosphere complex solution, local charge inversion is observed for a high anion concentration of tetravalent anions and the double-stranded DNA can be unwrapped from the nanosphere because of the local charge inversion near the nanosphere. Moreover, the helical structure of DNA is damaged when double-stranded DNA wraps around the nanosphere and the helical structure can be rebuilt when the double-stranded DNA unwraps from the nanosphere. This study can help us understand how to control the release of DNA in DNA–nanosphere complexes.

Graphical abstract: Wrapping/unwrapping transition of double-stranded DNA in DNA–nanosphere complexes induced by multivalent anions

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Publication details

The article was received on 25 Mar 2014, accepted on 11 Apr 2014 and first published on 11 Apr 2014


Article type: Paper
DOI: 10.1039/C4SM00652F
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Citation: Soft Matter, 2014,10, 4875-4884

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    Wrapping/unwrapping transition of double-stranded DNA in DNA–nanosphere complexes induced by multivalent anions

    A. Chai, Y. Jiang, Y. Zhang, L. He, D. Zhang and L. Zhang, Soft Matter, 2014, 10, 4875
    DOI: 10.1039/C4SM00652F

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