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Issue 26, 2013
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The effect of pH on the self-assembly of a collagen derived peptide amphiphile

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Abstract

Transitions in nanostructure driven by pH are observed for a self-assembling peptide amphiphile (PA) with a cationic pentapeptide headgroup. At pH 3, the PA forms flat tape-like structures, while at pH 4 the PA assembles into twisted right handed structures. These twisted structures transform again to flat tape-like structures at pH 7. In complete contrast, spherical micelles are observed at pH 2. These changes in response to pH may be relevant to biological and pharmaceutical applications of this PA in skincare.

Graphical abstract: The effect of pH on the self-assembly of a collagen derived peptide amphiphile

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Publication details

The article was received on 15 Apr 2013, accepted on 22 May 2013 and first published on 23 May 2013


Article type: Communication
DOI: 10.1039/C3SM51029H
Soft Matter, 2013,9, 6033-6036
  • Open access: Creative Commons BY license
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    The effect of pH on the self-assembly of a collagen derived peptide amphiphile

    A. Dehsorkhi, V. Castelletto, I. W. Hamley, J. Adamcik and R. Mezzenga, Soft Matter, 2013, 9, 6033
    DOI: 10.1039/C3SM51029H

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