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Issue 29, 2013
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Understanding and modulating the competitive surface-adsorption of proteins through coarse-grained molecular dynamics simulations

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Abstract

It is now well accepted that cellular responses to materials in a biological medium reflect greatly the adsorbed biomolecular layer, rather than the material itself. Here, we study by molecular dynamics simulations the competitive protein adsorption on a surface (Vroman effect), i.e. the non-monotonic behavior of the amount of protein adsorbed on a surface in contact with plasma as functions of contact time and plasma concentration. We find a complex behavior, with regimes during which small and large proteins are not necessarily competing between them, but are both competing with others in solution (“cooperative” adsorption). We show how the Vroman effect can be understood, controlled and inverted.

Graphical abstract: Understanding and modulating the competitive surface-adsorption of proteins through coarse-grained molecular dynamics simulations

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Article information


Submitted
21 Jan 2013
Accepted
21 Mar 2013
First published
16 Apr 2013

Soft Matter, 2013,9, 6978-6985
Article type
Paper

Understanding and modulating the competitive surface-adsorption of proteins through coarse-grained molecular dynamics simulations

P. Vilaseca, K. A. Dawson and G. Franzese, Soft Matter, 2013, 9, 6978
DOI: 10.1039/C3SM50220A

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