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Issue 37, 2012
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Lyophilised protein dynamics: more than just methyls?

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Abstract

Neutron spectroscopy has been used to probe picosecond to nanosecond dynamics in lyophilised apoferritin, insulin, superoxide dismutase and green fluorescent protein. These proteins have markedly different secondary structures yet similar CH3 compositions. Results suggest that while only CH3 activation is apparent in apoferritin, an enhanced dynamic environment presents itself in Ins, SOD and GfP. Our results hint at a structure dependent dynamic landscape.

Graphical abstract: Lyophilised protein dynamics: more than just methyls?

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Publication details

The article was received on 03 Jul 2012, accepted on 03 Aug 2012 and first published on 20 Aug 2012


Article type: Communication
DOI: 10.1039/C2SM26540K
Soft Matter, 2012,8, 9529-9532

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    Lyophilised protein dynamics: more than just methyls?

    M. T. F. Telling, L. Clifton, J. Combet, B. Frick, S. Howells and V. G. Sakai, Soft Matter, 2012, 8, 9529
    DOI: 10.1039/C2SM26540K

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