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Issue 37, 2012
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Novel pH responsive hydrogels for controlled cell adhesion and triggered surface detachment

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Abstract

In the field of tissue engineering, the development of novel switchable cell growth scaffolds and triggered substrate surfaces is desirable for manipulating detachment of cells. In this paper, two kinds of pH-responsive C2-cyclohexane based cell scaffold biomaterials (G1 and G2) have been designed and synthesized. The highlight is that they can induce detachment of cells from material's surface by slightly reducing the pH of culture medium in an acceptable range. The abilities to culture cells on hydrogel scaffolds and guide cells to detach without proteolytic enzyme treatment are very useful for their development in various biomedical applications.

Graphical abstract: Novel pH responsive hydrogels for controlled cell adhesion and triggered surface detachment

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Publication details

The article was received on 22 Mar 2012, accepted on 17 Jul 2012 and first published on 03 Aug 2012


Article type: Paper
DOI: 10.1039/C2SM26442K
Soft Matter, 2012,8, 9539-9544

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    Novel pH responsive hydrogels for controlled cell adhesion and triggered surface detachment

    X. Dou, X. Yang, P. Li, Z. Zhang, H. Schönherr, D. Zhang and C. Feng, Soft Matter, 2012, 8, 9539
    DOI: 10.1039/C2SM26442K

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