Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 24, 2012
Previous Article Next Article

Enhanced activity of cyclic transporter sequences driven by phase behavior of peptide–lipid complexes

Author affiliations

Abstract

We demonstrate that recently observed increases in cell permeation activity of cyclic peptides via transporter sequences are due to the underlying phase behavior of peptide–lipid complexes and their relation to the topological requirement of membrane permeation. We also show how these effects can be amplified by incorporating hydrophobicity in these sequences.

Graphical abstract: Enhanced activity of cyclic transporter sequences driven by phase behavior of peptide–lipid complexes

Back to tab navigation

Supplementary files

Article information


Submitted
22 Feb 2012
Accepted
13 Apr 2012
First published
18 May 2012

Soft Matter, 2012,8, 6430-6433
Article type
Communication

Enhanced activity of cyclic transporter sequences driven by phase behavior of peptide–lipid complexes

K. Zhao, U. Choe, D. T. Kamei and G. C. L. Wong, Soft Matter, 2012, 8, 6430
DOI: 10.1039/C2SM25405K

Social activity

Search articles by author

Spotlight

Advertisements