Issue 24, 2012
From the journal:

Soft Matter

Enhanced activity of cyclic transporter sequences driven by phase behavior of peptide–lipid complexes†

Kun Zhao,a   Uh-Joo Choe,a   Daniel T. Kameia  and  Gerard C. L. Wong*abc  

* Corresponding authors

a Department of Bioengineering, University of California, 420 Westwood Plaza, Los Angeles,, CA 90095, USA
E-mail: gclwong.ucla@gmail.com
Fax: +1 310-794-5956

b California NanoSystems Institute, University of California, Los Angeles, USA

c Department of Chemistry and Biochemistry, University of California, Los Angeles, USA

Abstract

We demonstrate that recently observed increases in cell permeation activity of cyclic peptides via transporter sequences are due to the underlying phase behavior of peptide–lipid complexes and their relation to the topological requirement of membrane permeation. We also show how these effects can be amplified by incorporating hydrophobicity in these sequences.

Graphical abstract: Enhanced activity of cyclic transporter sequences driven by phase behavior of peptide–lipid complexes

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Article information

DOI
https://doi.org/10.1039/C2SM25405K
Article type
Communication
Submitted
22 Feb 2012
Accepted
13 Apr 2012
First published
18 May 2012

Soft Matter, 2012,8, 6430-6433

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Enhanced activity of cyclic transporter sequences driven by phase behavior of peptide–lipid complexes

K. Zhao, U. Choe, D. T. Kamei and G. C. L. Wong, Soft Matter, 2012, 8, 6430 DOI: 10.1039/C2SM25405K

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