Issue 23, 2011
From the journal:

Soft Matter

Cationic liposomes are possible drug-delivery systems for HIV fusion inhibitor sifuvirtide†

Henri G. Franquelim,a   Filipa F. De-Sousa,a   A. Salomé Veiga,ab   Nuno C. Santosa  and  Miguel A. R. B. Castanho*a  

* Corresponding authors

a Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, Lisbon, Portugal
E-mail: macastanho@fm.ul.pt
Fax: +351 217999477
Tel: +351 217999485

b Chemical Biology Laboratory, National Cancer Institute, Frederick, Maryland, USA

Abstract

HIV-1 inhibitor sifuvirtide presents increased affinity for cationic dipalmitoylethyl-phosphatidylcholine (EDPPC) in contrast to viral/raft-mimicking (VRM) membranes. When associated to sifuvirtide, EDPPC-containing vesicles fuse with VRM vesicles. After fusion, the peptide co-localizes on VRM vesicles, indicating an effective delivery and concentration of sifuvirtide towards the viral and lipid raft vicinity.

Graphical abstract: Cationic liposomes are possible drug-delivery systems for HIV fusion inhibitor sifuvirtide

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Article information

DOI
https://doi.org/10.1039/C1SM06553J
Article type
Communication
Submitted
13 Aug 2011
Accepted
10 Oct 2011
First published
28 Oct 2011

Soft Matter, 2011,7, 11089-11092

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Cationic liposomes are possible drug-delivery systems for HIV fusion inhibitor sifuvirtide

H. G. Franquelim, F. F. De-Sousa, A. S. Veiga, N. C. Santos and M. A. R. B. Castanho, Soft Matter, 2011, 7, 11089 DOI: 10.1039/C1SM06553J

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