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Issue 21, 2011
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Electrospun silica/PLLA hybrid materials for skeletal regeneration

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Abstract

This paper presents the electrospinning of new silica/poly(L-lactic acid) (PLLA) based organic/inorganic sol–gel hybrid materials for skeletal defect regeneration. Here, hybrids are defined as inorganic and organic species interacting at the molecular level such that there are no distinguishable phases above the nanoscale. In previous hybrids, calcium has not been successfully incorporated into the silica network, limiting bioactivity. Here, an alkoxide source of calcium (calcium methoxyethoxide (CME)) was successfully used with a modified dual syringe reactive electrospinning (DSRS) setup to produce a calcium and silica containing PLLA sol–gel hybrid fibermat. Fibermats with continuous and homogeneous fibers were successfully produced that showed controlled and tailorable release of soluble silica in aqueous media. The CME-derived PLLA hybrid was observed to be hydrophilic and showed indication of bone-like apatite formation within 12 h of soaking in simulated body fluid (SBF). After soaking in SBF, the entire fiber surface was coated by a homogeneous thickness of apatite that had a plate-like crystal structure. The reversal of PLLA's hydrophobicity has tremendous implications on the biological properties of the material. All the electrospun materials were easy to handle and could be easily shaped into complex shapes. The tensile strength of the hybrid fibermats was found to be enhanced by the addition of silica, where a twofold increase in the tensile strength of 20 wt% silica containing PLLA fibermats compared to that of PLLA fibermats was observed.

Graphical abstract: Electrospun silica/PLLA hybrid materials for skeletal regeneration

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Publication details

The article was received on 22 Jun 2011, accepted on 11 Aug 2011 and first published on 06 Sep 2011


Article type: Paper
DOI: 10.1039/C1SM06171B
Soft Matter, 2011,7, 10241-10251

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    Electrospun silica/PLLA hybrid materials for skeletal regeneration

    G. Poologasundarampillai, B. Yu, J. R. Jones and T. Kasuga, Soft Matter, 2011, 7, 10241
    DOI: 10.1039/C1SM06171B

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