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Issue 20, 2010
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Designing biomimetic scaffolds for bone regeneration: why aim for a copy of mature tissue properties if nature uses a different approach?

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Abstract

This review aims to address the current limitations in biomaterial scaffold-based treatment strategies for bone defect healing and suggests new, alternative approaches that merit further investigation. The question of whether the biomaterial scaffold properties should mimic the natural extracellular matrix of mature tissue or some phase of the dynamic range of tissues observed during the healing process is discussed. Additionally, the authors advocate for a biomimetic approach, which uses the endogenous secondary fracture healing processes to inform the design of scaffold constructs. In particular, the mechanical environment is emphasized as an important factor influencing the clinical success of these constructs. The authors stress the need for a scaffolds design that provides an optimal mechanical environment for cell fate, supplies necessary signals and nutrition to the cells and, thus, more closely mimics the natural healing cascade.

Graphical abstract: Designing biomimetic scaffolds for bone regeneration: why aim for a copy of mature tissue properties if nature uses a different approach?

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Article information


Submitted
15 Apr 2010
Accepted
22 Jul 2010
First published
24 Aug 2010

Soft Matter, 2010,6, 4976-4987
Article type
Review Article

Designing biomimetic scaffolds for bone regeneration: why aim for a copy of mature tissue properties if nature uses a different approach?

B. M. Willie, A. Petersen, K. Schmidt-Bleek, A. Cipitria, M. Mehta, P. Strube, J. Lienau, B. Wildemann, P. Fratzl and G. Duda, Soft Matter, 2010, 6, 4976
DOI: 10.1039/C0SM00262C

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