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Issue 20, 2010
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Dense fibrillar collagen matrices for tissue repair

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Abstract

The preparation of dense fibrillar collagen matrices, through a sol/gel transition at variable concentrations, offers routes to produce a range of simple, non toxic materials. Concentrated hydrogels entrapping cells show enhanced properties in terms of reduced contraction and enhanced cell proliferation. Dense fibrillar matrices attain tissue like mechanical properties and show ultrastructures described in connective tissues, namely liquid crystalline cholesteric geometries. Their colonization by cells and possible association with a mineral phase in a tissue like manner validate their use as biomimetic materials for regenerative medicine.

Graphical abstract: Dense fibrillar collagen matrices for tissue repair

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Article information


Submitted
15 Apr 2010
Accepted
01 Jul 2010
First published
31 Aug 2010

Soft Matter, 2010,6, 4963-4967
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Dense fibrillar collagen matrices for tissue repair

M. M. Giraud Guille, C. Helary, S. Vigier and N. Nassif, Soft Matter, 2010, 6, 4963
DOI: 10.1039/C0SM00260G

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