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Issue 9, 2008
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Polymer-supported lipid shells, onions, and flowers†

Anna Bershteyn,a   José Chaparro,a   Richard Yau,a   Mikyung Kim,b   Ellis Reinherz,b   Luis Ferreira-Moitac  and  Darrell J. Irvine*a  
Author affiliations

* Corresponding authors

a Department of Materials Science and Engineering, and Biological Engineering, Massachusetts Institute of Technology, Room 8-425, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
E-mail: djirvine@mit.edu
Fax: +1 617 452 3293
Tel: +1 617 452 4174

b Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, HIM 418, Boston, MA 02115, USA
E-mail: ellis_reinherz@dfci.harvard.edu
Fax: +1 617 632 3351
Tel: +1 617 632 3412

c Cell Biology of the Immune System Unit, Institute of Molecular Medicine, Room P3B-40, Edificio Egas Moniz, Av. Prof Egas Moniz, 1649-028 Lisboa, Portugal
E-mail: lferreiramoita@gmail.com
Fax: +00351 217999504
Tel: +00351 217999512 ext. 47344

Abstract

Phospholipid-enveloped biodegradable polymer microparticles and nanoparticles synthesized by an emulsion–solvent evaporation process were characterized by confocal and cryoelectron microscopies to show that the lipid envelope exhibits two-dimensional fluidity and can be configured into ‘shell’, ‘onion’, or ‘flower’ nanostructures, depending on the quantity and composition of lipids employed in the synthesis.

Graphical abstract: Polymer-supported lipid shells, onions, and flowers

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Article information

https://doi.org/10.1039/B804933E
Submitted
26 Mar 2008
Accepted
30 Jun 2008
First published
09 Jul 2008
Soft Matter, 2008,4, 1787-1791
Article type
Communication
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Polymer-supported lipid shells, onions, and flowers

A. Bershteyn, J. Chaparro, R. Yau, M. Kim, E. Reinherz, L. Ferreira-Moita and D. J. Irvine, Soft Matter, 2008, 4, 1787
DOI: 10.1039/B804933E

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