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Issue 7, 2008
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Mechanical regulation of cell adhesion

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Abstract

Cellular adhesion against external forces is governed by both the equilibrium affinity of the involved receptor–ligand bonds and the mechanics of the cell. Certain receptors like integrins change their affinity as well as the mechanics of their anchorage to tune the adhesiveness. Whereas in the last few years the focus of integrin research has lain on the affinity regulation of the adhesion receptors, more recently the importance of cellular mechanics became apparent. Here, we focus on different aspects of the mechanical regulation of the cellular adhesiveness.

Graphical abstract: Mechanical regulation of cell adhesion

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Article information


Submitted
30 Oct 2007
Accepted
01 May 2008
First published
04 Jun 2008

Soft Matter, 2008,4, 1373-1387
Article type
Review Article

Mechanical regulation of cell adhesion

J. Schmitz and K. Gottschalk, Soft Matter, 2008, 4, 1373
DOI: 10.1039/B716805P

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