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Issue 4, 2008
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Spreading of bio-adhesive vesicles on DNA carpets

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Abstract

Cell-adhesion events involve often the formation of a contact region between phospholipid membranes decorated with a variety of bio-macromolecular species. We mimic here such hairy bio-adhesive contact zones by spreading phospholipid vesicles onto surfaces carpeted with end-grafted λ-phage DNA. Our study reveals that the spreading front acts as a scraper that strongly stretches the DNA molecules, and that the multiple bonds created during vesicle spreading effectively staple the stretched chains in the gap between the membrane and the substrate. The scraping and stapling mechanisms revealed here for the long DNA molecules are expected to also play a role in actual bio-adhesion events of cell walls and tissues.

Graphical abstract: Spreading of bio-adhesive vesicles on DNA carpets

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Supplementary files

Article information


Submitted
09 Oct 2007
Accepted
16 Jan 2008
First published
20 Feb 2008

Soft Matter, 2008,4, 828-832
Article type
Paper

Spreading of bio-adhesive vesicles on DNA carpets

M. Hisette, P. Haddad, T. Gisler, C. M. Marques and A. P. Schröder, Soft Matter, 2008, 4, 828
DOI: 10.1039/B715530A

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