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Issue 6, 2008
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Condensed multilamellar structure of a complex of DNA with an amphiphilic block copolymer

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Abstract

Deoxyribonucleic acid (DNA) is an attractive building block for self-assembled nanostructures, because the anionic phosphate group and the base moiety allow it to bind with a broad spectrum of organic and inorganic species through ionic and hydrogen bonding. Here we present a hierarchical structure formed by the ionic complex of DNA with an amphiphilic block copolymer comprising a cationic block. Upon the complexation the cationic block chains wrap around DNA for charge matching and the microphase separation between the hydrophobic block and the hydrophilic component yields a multilamellar structure with liquid crystalline ordering of the DNA chains condensed in the hydrophilic microdomains. Each hydrophilic lamellar domain is found to contain two DNA sublayers separated by a thin water gap, with each sublayer comprising two rows of densely packed DNA chains to lower the interfacial free energy for the present system with strong polar–nonpolar repulsion.

Graphical abstract: Condensed multilamellar structure of a complex of DNA with an amphiphilic block copolymer

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Article information


Submitted
02 Oct 2007
Accepted
13 Mar 2008
First published
07 Apr 2008

Soft Matter, 2008,4, 1306-1312
Article type
Paper

Condensed multilamellar structure of a complex of DNA with an amphiphilic block copolymer

C. Su, S. Yeh, W. Lai, H. Chen, M. H. Rahman, R. Wu, H. Lin and W. Liu, Soft Matter, 2008, 4, 1306
DOI: 10.1039/B715045H

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