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Issue 3, 2007
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Cellular chemomechanics at interfaces: sensing, integration and response

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Abstract

Living cells are complex entities whose remarkable, emergent capacity to sense, integrate, and respond to environmental cues relies on an intricate series of interactions among the cell's macromolecular components. Defects in mechanosensing, transduction,or responses underlie many diseases such as cancers, immune disorders, cardiac hypertrophy, genetic malformations, and neuropathies. Here, we highlight micro- and nanotechnology-based tools that have been used to study how chemical and mechanical cues modulate the responses of single cells in contact with the extracellular environment. Understanding the physical aspects of these complex processes at the micro- and nanometer scale could produce profound and fundamental new insights into how the processes of cell migration, metastasis, immune function and other areas which are regulated by mechanical forces.

Graphical abstract: Cellular chemomechanics at interfaces: sensing, integration and response

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Publication details

The article was received on 26 Sep 2006, accepted on 07 Nov 2006 and first published on 15 Jan 2007


Article type: Review Article
DOI: 10.1039/B614008D
Soft Matter, 2007,3, 307-326

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    Cellular chemomechanics at interfaces: sensing, integration and response

    P. P. Girard, E. A. Cavalcanti-Adam, R. Kemkemer and J. P. Spatz, Soft Matter, 2007, 3, 307
    DOI: 10.1039/B614008D

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