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Issue 12, 2006
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Self-assembly and applications of biomimetic and bioactive peptide-amphiphiles

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Abstract

Peptide-amphiphiles are amphiphilic structures with a hydrophilic peptide headgroup that incorporates a bioactive sequence and has the potential to form distinct structures, and a hydrophobic tail that serves to align the headgroup, drive self-assembly, and induce secondary and tertiary conformations. In this paper we review the different self-assembled structures of peptide-amphiphiles that range from micelles and nanofibers, to patterned membranes. We also describe several examples where peptide-amphiphiles have found applications as soft bioactive materials for model studies of bioadhesion and characterization of different cellular phenomena, as well as scaffolds for tissue engineering, regenerative medicine, and targeted drug delivery.

Graphical abstract: Self-assembly and applications of biomimetic and bioactive peptide-amphiphiles

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Article information


Submitted
29 Jun 2006
Accepted
16 Aug 2006
First published
18 Oct 2006

Soft Matter, 2006,2, 1015-1024
Article type
Review Article

Self-assembly and applications of biomimetic and bioactive peptide-amphiphiles

E. Kokkoli, A. Mardilovich, A. Wedekind, E. L. Rexeisen, A. Garg and J. A. Craig, Soft Matter, 2006, 2, 1015
DOI: 10.1039/B608929A

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