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Issue 17, 2021

Preparation and reactions of polyfunctional magnesium and zinc organometallics in organic synthesis

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Abstract

Polyfunctional organometallics of magnesium and zinc are readily prepared from organic halides via a direct metal insertion in the presence of LiCl or a Br/Mg-exchange using iPrMgCl·LiCl (turbo-Grignard) or related reagents. Alternatively, such functionalized organometallics are prepared by metalations with TMP-bases (TMP = 2,2,6,6-tetramethylpiperidyl). The scope of these methods is described as well as applications in new Co- or Fe-catalyzed cross-couplings or aminations. It is shown that the use of a continous flow set-up considerably expands the field of applications of these methods and further allows the preparation of highly reactive organosodium reagents.

Graphical abstract: Preparation and reactions of polyfunctional magnesium and zinc organometallics in organic synthesis

Article information


Submitted
03 Feb 2021
Accepted
09 Mar 2021
First published
16 Mar 2021

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2021,12, 6011-6019
Article type
Perspective

Preparation and reactions of polyfunctional magnesium and zinc organometallics in organic synthesis

A. Kremsmair, J. H. Harenberg, K. Schwärzer, A. Hess and P. Knochel, Chem. Sci., 2021, 12, 6011 DOI: 10.1039/D1SC00685A

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