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Issue 5, 2021
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A chiroptical approach for the absolute stereochemical determination of P-stereogenic centers

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Abstract

A simple chiroptical solution for the absolute stereochemical determination for asymmetric phosphorus V stereocenters is presented. Strong coordination of the phosphorus oxide with the Zn-metallo center of the racemic host Zn-MAPOL 2 leads to an induced axial chirality of the host, yielding a strong ECCD signal. A mnemonic is proposed to correlate the asymmetry of the guest molecule with the observed ECCD signal.

Graphical abstract: A chiroptical approach for the absolute stereochemical determination of P-stereogenic centers

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Article information


Submitted
25 May 2020
Accepted
15 Nov 2020
First published
07 Dec 2020

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2021,12, 1750-1755
Article type
Edge Article

A chiroptical approach for the absolute stereochemical determination of P-stereogenic centers

D. Chakraborty, H. Gholami, A. Sarkar, L. A. Joyce, J. E. Jackson and B. Borhan, Chem. Sci., 2021, 12, 1750
DOI: 10.1039/D0SC02940H

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