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Issue 40, 2020

Diverse strategies for transition metal catalyzed distal C(sp3)–H functionalizations

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Abstract

Transition metal catalyzed C(sp3)–H functionalization is a rapidly growing field. Despite severe challenges, distal C–H functionalizations of aliphatic molecules by overriding proximal positions have witnessed tremendous progress. While usage of stoichiometric directing groups played a crucial role, reactions with catalytic transient directing groups or methods without any directing groups are gaining more attention due to their practicality. Various innovative strategies, slowly but steadily, circumvented issues related to remote functionalizations of aliphatic molecules. A systematic compilation has been presented here to provide insights into the recent developments and future challenges in the field. The Present perspective is expected to open up a new dimension and provide an avenue for deep insights into the distal C(sp3)–H functionalizations that could be applied routinely in various pharmaceutical and agrochemical industries.

Graphical abstract: Diverse strategies for transition metal catalyzed distal C(sp3)–H functionalizations

Article information


Submitted
25 Aug 2020
Accepted
26 Sep 2020
First published
28 Sep 2020

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2020,11, 10887-10909
Article type
Perspective

Diverse strategies for transition metal catalyzed distal C(sp3)–H functionalizations

J. Das, S. Guin and D. Maiti, Chem. Sci., 2020, 11, 10887 DOI: 10.1039/D0SC04676K

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