Jump to main content
Jump to site search

Issue 30, 2020
Previous Article Next Article

Engineering a highly selective probe for ratiometric imaging of H2Sn and revealing its signaling pathway in fatty liver disease

Author affiliations

Abstract

Hydrogen polysulfides (H2Sn, n > 1) have continuously been proved to act as important signal mediators in many physiological processes. However, the physiological role of H2Sn and their signaling pathways in complex diseases, such as the most common liver disease, nonalcoholic fatty liver disease (NAFLD), have not been elucidated due to lack of suitable tools for selective detection of intracellular H2Sn. Herein, we adopted a general and practical strategy including recognition site screening, construction of a ratiometric probe and self-assembly of nanoparticles, to significantly improve the probes' selectivity, photostability and biocompatibility. The ratiometric probe PPG-Np-RhPhCO selectively responds to H2Sn, avoiding interaction with biothiol and persulfide. Moreover, this probe was applied to image H2Sn in NAFLD for the first time and reveal the H2Sn generation pathways in the cell model of drug-treated NAFLD. The pathway of H2Sn revealed by PPG-Np-RhPhCO provides significant insights into the roles of H2Sn in NAFLD and future drug development.

Graphical abstract: Engineering a highly selective probe for ratiometric imaging of H2Sn and revealing its signaling pathway in fatty liver disease

Back to tab navigation

Supplementary files

Article information


Submitted
16 Jun 2020
Accepted
09 Jul 2020
First published
09 Jul 2020

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2020,11, 7991-7999
Article type
Edge Article

Engineering a highly selective probe for ratiometric imaging of H2Sn and revealing its signaling pathway in fatty liver disease

W. Li, L. Wang, S. Yin, H. Lai, L. Yuan and X. Zhang, Chem. Sci., 2020, 11, 7991
DOI: 10.1039/D0SC03336G

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements