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Issue 31, 2020

Salient features of the aza-Wacker cyclization reaction

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The intramolecular aza-Wacker reaction has unparalleled potential for the site-selective amination of olefins, but it is perhaps underappreciated relative to other alkene oxidations. The first part of this review makes the distinction between classical and tethered aza-Wacker cyclization reactions and summarizes examples of the latter. The second portion focuses on developments in asymmetric aza-Wacker cyclization technology. The final part of the review summarizes applications of all classes of aza-Wacker cyclization reactions to natural product assembly.

Graphical abstract: Salient features of the aza-Wacker cyclization reaction

Article information

05 May 2020
20 Jul 2020
First published
21 Jul 2020

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2020,11, 8073-8088
Article type

Salient features of the aza-Wacker cyclization reaction

A. A. Thomas, S. Nagamalla and S. Sathyamoorthi, Chem. Sci., 2020, 11, 8073 DOI: 10.1039/D0SC02554B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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