Issue 43, 2019

Rhodium-catalyzed asymmetric intramolecular hydroarylation of allenes: access to functionalized benzocycles

Abstract

A rhodium-catalyzed regio- and enantioselective cyclization of tethered allenylbenzenes is reported. Employing a RhI/Josiphos catalytic system a diverse set of 6-membered, α-chiral benzocycles were obtained, scaffolds found in many bioactive compounds. Moreover, a gram scale reaction as well as the application of suitable transformations are demonstrated.

Graphical abstract: Rhodium-catalyzed asymmetric intramolecular hydroarylation of allenes: access to functionalized benzocycles

Supplementary files

Article information

Article type
Edge Article
Submitted
05 Aug 2019
Accepted
06 Sep 2019
First published
10 Sep 2019
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2019,10, 10048-10052

Rhodium-catalyzed asymmetric intramolecular hydroarylation of allenes: access to functionalized benzocycles

D. Berthold, J. Klett and B. Breit, Chem. Sci., 2019, 10, 10048 DOI: 10.1039/C9SC03894A

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