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Issue 29, 2019

A tetrahedral molecular cage with a responsive vertex

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Dynamic covalent chemistry (DCC) is a widely used method for the self-assembly of three-dimensional molecular architectures. The orthogonality of dynamic reactions is emerging as a versatile strategy for controlling product distributions in DCC, yet the application of this approach to the synthesis of 3D organic molecular cages is limited. We report the first system which employs the orthogonality of alkyne metathesis and dynamic imine exchange to prepare a molecular cage with a reversibly removable vertex. This study demonstrates the rational and controlled application of chemical orthogonality in DCC to prepare organic cages of expanded functionality which respond to chemical stimuli.

Graphical abstract: A tetrahedral molecular cage with a responsive vertex

Supplementary files

Article information

25 Apr 2019
09 Jun 2019
First published
13 Jun 2019

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2019,10, 7043-7048
Article type
Edge Article

A tetrahedral molecular cage with a responsive vertex

C. C. Pattillo and J. S. Moore, Chem. Sci., 2019, 10, 7043 DOI: 10.1039/C9SC02047K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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