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Issue 26, 2019
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Site-selective C–H activation and regiospecific annulation using propargylic carbonates

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Abstract

Herein we describe an unprecedented RuII-catalyzed site-selective and regiospecific annulation of benzoic acids with propargylic carbonates. The weakly coordinating carboxylic acid moiety outperformed other typically used directing groups in C–H activation, including ketone, nitrile, sulfonamide, amide and strongly coordinating nitrogen heterocycles. This is an important step towards the application of C–H activation reactions in complex (functional) real-world molecules.

Graphical abstract: Site-selective C–H activation and regiospecific annulation using propargylic carbonates

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Supplementary files

Article information


Submitted
07 Apr 2019
Accepted
24 May 2019
First published
27 May 2019

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2019,10, 6560-6564
Article type
Edge Article

Site-selective C–H activation and regiospecific annulation using propargylic carbonates

Q. Lu, S. Mondal, S. Cembellín, S. Greßies and F. Glorius, Chem. Sci., 2019, 10, 6560
DOI: 10.1039/C9SC01703H

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