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Issue 20, 2019
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Synthesis of glycopolymers with specificity for bacterial strains via bacteria-guided polymerization

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Abstract

Identifying probiotics and pathogens is of great interest to the health of the human body. It is critical to develop microbiota-targeted therapies to have high specificity including strain specificity. In this study, we have utilized E. coli MG1655 bacteria as living templates to synthesize glycopolymers in situ with high selectivity. By this bacteria-sugar monomer-aptation-polymerization (BS-MAP) method, we have obtained glycopolymers from the surface of bacteria which can recognize template bacteria from two strains of E. coli and the specific bacteria-binding ability of glycopolymers was confirmed by both bacterial aggregation experiment and QCM-D measurements. Furthermore, the synthesized glycopolymers have shown a powerful inhibitory ability which can prevent bacteria from harming cells in both anti-infection and co-culture tests.

Graphical abstract: Synthesis of glycopolymers with specificity for bacterial strains via bacteria-guided polymerization

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Supplementary files

Article information


Submitted
13 Dec 2018
Accepted
15 Apr 2019
First published
18 Apr 2019

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2019,10, 5251-5257
Article type
Edge Article

Synthesis of glycopolymers with specificity for bacterial strains via bacteria-guided polymerization

Y. Luo, Y. Gu, R. Feng, J. Brash, Ahmed M. Eissa, D. M. Haddleton, G. Chen and H. Chen, Chem. Sci., 2019, 10, 5251
DOI: 10.1039/C8SC05561K

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

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