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Issue 2, 2019
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Nuclear singlet multimers (NUSIMERs) with long-lived singlet states

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Abstract

Magnetic resonance (NMR) is a powerful tool in chemical analysis, structure determination and in medical diagnostics. Developing novel biological sensors for this field holds promise to better investigate protein structures or target diseases more efficiently. Herein, we explore nuclear spin singlet states in dendritic macromolecules as a platform molecule to develop stimuli responsive probes. We have developed a nuclear singlet multimer (NUSIMER) based on a generation 5 poly(amidoamine) dendrimer (PAMAM) which contains on average about 90 accessible nuclear spin singlet states with lifetimes up to 10-fold longer than the T1 relaxation times (up to 10 seconds Tsvs. T1 < 0.5 seconds) in a single molecule. We demonstrate little influence on the singlet lifetime in phosphate buffer (H2O) and a high viscosity gel environment in the presence of paramagnetic oxygen. Additionally, we demonstrate an increase in singlet lifetime upon the release of a protective chemical moiety from the NUSIMER following a stimulus, whereby no change in longitudinal relaxation time is observed. The robustness and change in singlet lifetime of the NUSIMER holds promise for the development of a novel type of biosensors.

Graphical abstract: Nuclear singlet multimers (NUSIMERs) with long-lived singlet states

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Publication details

The article was received on 27 Jun 2018, accepted on 24 Oct 2018 and first published on 25 Oct 2018


Article type: Edge Article
DOI: 10.1039/C8SC02831A
Citation: Chem. Sci., 2019,10, 413-417
  • Open access: Creative Commons BY license
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    Nuclear singlet multimers (NUSIMERs) with long-lived singlet states

    P. Saul, S. Mamone and S. Glöggler, Chem. Sci., 2019, 10, 413
    DOI: 10.1039/C8SC02831A

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