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Issue 36, 2018
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Phosphorescent iridium(iii) complexes capable of imaging and distinguishing between exogenous and endogenous analytes in living cells

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Abstract

Many luminescent probes have been developed for intracellular imaging and sensing. During cellular luminescence sensing, it is difficult to distinguish species generated inside cells from those internalized from extracellular environments since they are chemically the same and lead to the same luminescence response of the probes. Considering that endogenous species usually give more information about the physiological and pathological parameters of the cells while internalized species often reflect the extracellular environmental conditions, we herein reported a series of cyclometalated iridium(III) complexes as phosphorescent probes that are partially retained in the cell membrane during their cellular uptake. The utilization of the probes for sensing and distinguishing between exogenous and endogenous analytes has been demonstrated using hypoxia and hypochlorite as two examples of target analytes. The endogenous analytes lead to the luminescence response of the intracellular probes while the exogenous analytes are reported by the probes retained in the cell membrane during their internalization.

Graphical abstract: Phosphorescent iridium(iii) complexes capable of imaging and distinguishing between exogenous and endogenous analytes in living cells

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Supplementary files

Article information


Submitted
06 Jul 2018
Accepted
31 Jul 2018
First published
03 Aug 2018

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2018,9, 7236-7240
Article type
Edge Article

Phosphorescent iridium(III) complexes capable of imaging and distinguishing between exogenous and endogenous analytes in living cells

K. Y. Zhang, T. Zhang, H. Wei, Q. Wu, S. Liu, Q. Zhao and W. Huang, Chem. Sci., 2018, 9, 7236
DOI: 10.1039/C8SC02984A

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