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Issue 33, 2018
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Nickel(0)-catalyzed linear-selective hydroarylation of unactivated alkenes and styrenes with aryl boronic acids

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Abstract

Herein, we describe the first linear-selective hydroarylation reaction of unactivated alkenes and styrenes with aryl boronic acids, which was achieved by introducing a directing group on the alkenes. This efficient, scalable reaction serves as a method for modular assembly of structurally diverse alkyl arenes, including γ-aryl butyric acid derivatives, which are widely utilized as chemical building blocks for the synthesis of various drugs and other biologically active compounds.

Graphical abstract: Nickel(0)-catalyzed linear-selective hydroarylation of unactivated alkenes and styrenes with aryl boronic acids

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Publication details

The article was received on 11 May 2018, accepted on 17 Jul 2018 and first published on 18 Jul 2018


Article type: Edge Article
DOI: 10.1039/C8SC02101E
Citation: Chem. Sci., 2018,9, 6839-6843
  • Open access: Creative Commons BY-NC license
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    Nickel(0)-catalyzed linear-selective hydroarylation of unactivated alkenes and styrenes with aryl boronic acids

    H. Lv, L. Xiao, D. Zhao and Q. Zhou, Chem. Sci., 2018, 9, 6839
    DOI: 10.1039/C8SC02101E

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