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Issue 26, 2018
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Iridium-catalyzed enantioselective direct vinylogous allylic alkylation of coumarins

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Abstract

The first iridium-catalyzed enantioselective vinylogous allylic alkylation of coumarins is presented. Using easily accessible linear allylic carbonates as the allylic electrophile, this reaction installs unfunctionalized allyl groups at the γ-position of 4-methylcoumarins in an exclusively branched-selective manner generally in high yields with an excellent level of enantioselectivity (up to 99 : 1 er).

Graphical abstract: Iridium-catalyzed enantioselective direct vinylogous allylic alkylation of coumarins

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Article information


Submitted
07 May 2018
Accepted
03 Jun 2018
First published
04 Jun 2018

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2018,9, 5767-5772
Article type
Edge Article

Iridium-catalyzed enantioselective direct vinylogous allylic alkylation of coumarins

R. Sarkar, S. Mitra and S. Mukherjee, Chem. Sci., 2018, 9, 5767
DOI: 10.1039/C8SC02041H

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