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Issue 28, 2018
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Probing molecular dynamics with hyperpolarized ultrafast Laplace NMR using a low-field, single-sided magnet

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Abstract

Laplace NMR (LNMR) offers deep insights on diffusional and rotational motion of molecules. The so-called “ultrafast” approach, based on spatial data encoding, enables one to carry out a multidimensional LNMR experiment in a single scan, providing from 10 to 1000-fold acceleration of the experiment. Here, we demonstrate the feasibility of ultrafast diffusion–T2 relaxation correlation (DT2) measurements with a mobile, low-field, relatively low-cost, single-sided NMR magnet. We show that the method can probe a broad range of diffusion coefficients (at least from 10−8 to 10−12 m2 s−1) and reveal multiple components of fluids in heterogeneous materials. The single-scan approach is demonstrably compatible with nuclear spin hyperpolarization techniques because the time-consuming hyperpolarization process does not need to be repeated. Using dynamic nuclear polarization (DNP), we improved the NMR sensitivity of water molecules by a factor of 105 relative to non-hyperpolarized NMR in the 0.3 T field of the single-sided magnet. This enabled us to acquire a DT2 map in a single, 22 ms scan, despite the low field and relatively low mole fraction (0.003) of hyperpolarized water. Consequently, low-field, hyperpolarized ultrafast LNMR offers significant prospects for advanced, mobile, low-cost and high-sensitivity chemical and medical analysis.

Graphical abstract: Probing molecular dynamics with hyperpolarized ultrafast Laplace NMR using a low-field, single-sided magnet

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Supplementary files

Article information


Submitted
21 Mar 2018
Accepted
27 Jun 2018
First published
28 Jun 2018

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2018,9, 6143-6149
Article type
Edge Article

Probing molecular dynamics with hyperpolarized ultrafast Laplace NMR using a low-field, single-sided magnet

J. N. King, A. Fallorina, J. Yu, G. Zhang, V. Telkki, C. Hilty and T. Meldrum, Chem. Sci., 2018, 9, 6143
DOI: 10.1039/C8SC01329B

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