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Issue 19, 2018
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Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins

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Abstract

Bio-imaging techniques alternative to fluorescence microscopy are gaining increasing interest as complementary tools to visualize and analyze biological systems. Among them, X-ray fluorescence microspectroscopy provides information on the local content and distribution of heavy elements (Z ≥ 14) in cells or biological samples. In this context, similar tools to those developed for fluorescence microscopy are desired, including chemical probes or tags. In this work, we study rhenium complexes as a convenient and sensitive probe for X-ray fluorescence microspectroscopy. We demonstrate their ability to label and sense exogenously incubated or endogenous proteins inside cells.

Graphical abstract: Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins

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Supplementary files

Article information


Submitted
23 Feb 2018
Accepted
13 Apr 2018
First published
13 Apr 2018

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2018,9, 4483-4487
Article type
Edge Article

Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins

S. Hostachy, M. Masuda, T. Miki, I. Hamachi, S. Sagan, O. Lequin, K. Medjoubi, A. Somogyi, N. Delsuc and C. Policar, Chem. Sci., 2018, 9, 4483
DOI: 10.1039/C8SC00886H

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