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Issue 20, 2018
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A self-assembling luminescent lanthanide molecular nanoparticle with potential for live cell imaging

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Abstract

Four luminescent 32-metal Cd–Tb nanoclusters, [Tb8Cd24(L1)12(OAc)48] (1), [Tb8Cd24(L2)12(OAc)48] (2), [Tb8Cd24(L3)12(OAc)48] (3) and [Tb8Cd24(L2)12(1,4-BDC)4(OAc)38(OH)2] (4), were constructed from three specially designed chain-like Schiff base ligands H2L1–3 with flexible carbon–carbon backbones containing 5, 6 and 10 methylene units, respectively. The clusters exhibit drum-like structures and can be imaged using transmission electron microscopy (TEM). In addition to the Schiff base ligands (the primary energy transfer donors), four 1,4-BDC bridging units were successfully introduced into the structure of 4. In addition to providing increased structural stability, the 1,4-BDC units act as secondary energy transfer donors providing extra energy for lanthanide luminescence, which results in improved luminescence properties when compared to those of the related Cd–Ln nanoclusters without 1,4-BDC units. In vitro investigations on 4 with SGC and PANC cancer cells revealed an accumulation of the molecular nanoparticles in the cells, as confirmed by confocal microscopy. The cytotoxicity of 4 toward the SGC and PANC cells is moderate (IC50 values of 4 lie in the range of 15–60 μM). ICP-MS analysis reveals that cellular uptakes of 4 in 1000 SGC and PANC cells after treatment for 3 hours are 0.0094 pmol and 0.015 pmol, respectively.

Graphical abstract: A self-assembling luminescent lanthanide molecular nanoparticle with potential for live cell imaging

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Supplementary files

Article information


Submitted
08 Feb 2018
Accepted
23 Apr 2018
First published
26 Apr 2018

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2018,9, 4630-4637
Article type
Edge Article

A self-assembling luminescent lanthanide molecular nanoparticle with potential for live cell imaging

X. Yang, S. Wang, Y. Zhang, G. Liang, T. Zhu, L. Zhang, S. Huang, D. Schipper and R. A. Jones, Chem. Sci., 2018, 9, 4630
DOI: 10.1039/C8SC00650D

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