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Issue 1, 2018
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A lesson for site-selective C–H functionalization on 2-pyridones: radical, organometallic, directing group and steric controls

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Abstract

A 2-pyridone ring is a frequently occurring subunit in natural products, biologically active compounds, and pharmaceutical targets. Thus, the selective synthesis of substituted 2-pyridone derivatives through decoration and/or formation of pyridone rings has been one of the important longstanding subjects in organic synthetic chemistry. This minireview focuses on recent advances in site-selective C–H functionalization on 2-pyridone. The reported procedures are categorized according to the site selectivity that is achieved, and the substrate scope, limitations, mechanism, and controlling factors are briefly summarized.

Graphical abstract: A lesson for site-selective C–H functionalization on 2-pyridones: radical, organometallic, directing group and steric controls

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Article information


Submitted
18 Oct 2017
Accepted
26 Nov 2017
First published
27 Nov 2017

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2018,9, 22-32
Article type
Minireview

A lesson for site-selective C–H functionalization on 2-pyridones: radical, organometallic, directing group and steric controls

K. Hirano and M. Miura, Chem. Sci., 2018, 9, 22
DOI: 10.1039/C7SC04509C

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