Issue 3, 2018

Amide synthesis via nickel-catalysed reductive aminocarbonylation of aryl halides with nitroarenes

Abstract

Aminocarbonylation of aryl halides is one of the most useful methods in amide synthesis, but nitroarenes have not been used as a nitrogen source in this method even though they are more economical and accessible than anilines. Reported here is the development of nickel catalysis for the first three-component reactions of aryl halides, Co2(CO)8, and nitroarenes under reductive conditions to produce aryl amides. A wide range of (hetero)aryl iodides and bromides as well as nitro(hetero)arenes are suitable reaction partners, and high functional group compatibility has been achieved. The method might be used for the streamlined synthesis of aryl amides.

Graphical abstract: Amide synthesis via nickel-catalysed reductive aminocarbonylation of aryl halides with nitroarenes

Supplementary files

Article information

Article type
Edge Article
Submitted
08 Sep 2017
Accepted
04 Nov 2017
First published
06 Nov 2017
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2018,9, 655-659

Amide synthesis via nickel-catalysed reductive aminocarbonylation of aryl halides with nitroarenes

C. W. Cheung, M. Leendert Ploeger and X. Hu, Chem. Sci., 2018, 9, 655 DOI: 10.1039/C7SC03950F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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