Issue 2, 2018

Challenges and opportunities for alkane functionalisation using molecular catalysts

Abstract

The conversion of vast low-value saturated hydrocarbons into valuable chemicals is of great interest. Thanks to the progression of organometallic and coordination chemistry, transition metal catalysed C sp3–H bond functionalisation has now become a powerful tool for alkane transformations. Specifically, methods for alkane functionalisation include radical initiated C–H functionalisation, carbene/nitrene insertion, and transition metal catalysed C–H bond activation. This perspective provides a systematic and concise overview of each protocol, highlighting the factors that govern regioselectivity in these reactions. The challenges of the existing catalytic tactics and future directions for catalyst development in this field will be presented.

Graphical abstract: Challenges and opportunities for alkane functionalisation using molecular catalysts

Article information

Article type
Perspective
Submitted
17 Aug 2017
Accepted
07 Nov 2017
First published
09 Nov 2017
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2018,9, 288-299

Challenges and opportunities for alkane functionalisation using molecular catalysts

X. Tang, X. Jia and Z. Huang, Chem. Sci., 2018, 9, 288 DOI: 10.1039/C7SC03610H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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