Issue 8, 2017
From the journal:

Chemical Science

Synthesis and evaluation of MR probes for targeted-reporter imaging†

Kirti Dhingra Verma,‡a   Justin O. Massing,‡b   Sarah G. Kamper,b   Christiane E. Carney,b   Keith W. MacRenaris,b   James P. Basilion*a  and  Thomas J. Meade ORCID logo *b  

* Corresponding authors

a Department of Biomedical Engineering, Case Center for Imaging Research, The NFCR Center for Molecular Imaging, Case Western Reserve University, Cleveland, Ohio 44106-7207, USA

b Department of Chemistry, Molecular Biosciences, Neurobiology, Biomedical Engineering, and Radiology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA

Abstract

Visualizing disease heterogeneity remains a challenging task since most imaging agents are targeted to a single receptor. We describe the development of an MR platform able to report on multiple molecular events. Enzyme activation and enhanced cellular uptake of this modular probe make it suitable for subsequent targeted-reporter imaging applications.

Graphical abstract: Synthesis and evaluation of MR probes for targeted-reporter imaging

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Article information

DOI
https://doi.org/10.1039/C7SC02217D
Article type
Edge Article
Submitted
16 May 2017
Accepted
10 Jun 2017
First published
13 Jun 2017
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2017,8, 5764-5768

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Synthesis and evaluation of MR probes for targeted-reporter imaging

K. D. Verma, J. O. Massing, S. G. Kamper, C. E. Carney, Keith W. MacRenaris, J. P. Basilion and T. J. Meade, Chem. Sci., 2017, 8, 5764 DOI: 10.1039/C7SC02217D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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