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Issue 9, 2017
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Photochromic coenzyme Q derivatives: switching redox potentials with light

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Abstract

Coenzyme Q is an important redox cofactor involved in a variety of cellular processes, and is thus found in several cell compartments. We report a photochromic derivative of coenzyme Q that combines the molecular structures of the redox active cofactor and a photochromic dye. Light irradiation triggers an electronic rearrangement reversibly changing the redox potential. We used this effect to control the intermolecular redox reaction of the photochromic coenzyme Q derivative with dihydropyridine in solution by light irradiation. On mitochondria, the altered redox properties showed an effect on the respiratory chain. The experiments demonstrate that the redox reactions can be initiated inside the system of interest through irradiation with light and the accompanied photoisomerization.

Graphical abstract: Photochromic coenzyme Q derivatives: switching redox potentials with light

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Supplementary files

Article information


Submitted
18 Feb 2017
Accepted
19 Jul 2017
First published
20 Jul 2017

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2017,8, 6474-6483
Article type
Edge Article

Photochromic coenzyme Q derivatives: switching redox potentials with light

N. A. Simeth, A. C. Kneuttinger, R. Sterner and B. König, Chem. Sci., 2017, 8, 6474
DOI: 10.1039/C7SC00781G

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    [Original citation] - Published by The Royal Society of Chemistry.

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