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Issue 4, 2017
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Zwitterionic near infrared fluorescent agents for noninvasive real-time transcutaneous assessment of kidney function

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Abstract

We developed novel zwitterionic near infrared (NIR) fluorescent agents (ABZWCY-HPβCD and AAZWCY-HPβCD), which exhibit favorable hydrophilicity, low plasma protein binding, high stability and non-toxicity. These attractive characteristics ensure that they are excreted rapidly, without any skin accumulation or metabolism in vivo. More importantly, zwitterionic HPβCD based agents can be efficiently filtrated by the glomerulus and completely excreted through the kidneys into urine without reabsorption or secretion in the kidney proximal tubule. Relying on these novel zwitterionic NIR agents and a transcutaneous device, we demonstrate a rapid, robust and biocompatible approach for assessing kidney function in rat models of both healthy rats and those with kidney disease, without the need for time-consuming blood/urine sample preparation. Our work provides a promising tool for in vivo real-time non-invasive kidney function assessment in preclinical applications.

Graphical abstract: Zwitterionic near infrared fluorescent agents for noninvasive real-time transcutaneous assessment of kidney function

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Supplementary files

Article information


Submitted
16 Nov 2016
Accepted
08 Jan 2017
First published
11 Jan 2017

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2017,8, 2652-2660
Article type
Edge Article

Zwitterionic near infrared fluorescent agents for noninvasive real-time transcutaneous assessment of kidney function

J. Huang, S. Weinfurter, C. Daniele, R. Perciaccante, R. Federica, L. Della Ciana, J. Pill and N. Gretz, Chem. Sci., 2017, 8, 2652
DOI: 10.1039/C6SC05059J

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