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Issue 3, 2017
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Light responsive metal–organic frameworks as controllable CO-releasing cell culture substrates

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Abstract

A new carbon monoxide (CO)-releasing material has been developed by embedding a manganese carbonyl complex, MnBr(bpydc)(CO)3 (bpydc = 5,5′-dicarboxylate-2,2′-bipyridine) into a highly robust Zr(IV)-based metal–organic framework (MOF). Efficient and controllable CO-release was achieved under exposure to low intensity visible light. Size-controllable nanocrystals of the photoactive MOF were obtained and their CO-releasing properties were correlated with their crystal sizes. The photoactive crystals were processed into cellular substrates with a biocompatible polymer matrix, and the light-induced delivery of CO and its subsequent cellular uptake were monitored using a fluorescent CO-probe. The results discussed here demonstrate a new opportunity to use MOFs as macromolecular scaffolds towards CO-releasing materials and the advantage of MOFs for high CO payloads, which is essential in future therapeutic applications.

Graphical abstract: Light responsive metal–organic frameworks as controllable CO-releasing cell culture substrates

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Supplementary files

Article information


Submitted
31 Oct 2016
Accepted
21 Dec 2016
First published
21 Dec 2016

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2017,8, 2381-2386
Article type
Edge Article

Light responsive metal–organic frameworks as controllable CO-releasing cell culture substrates

S. Diring, A. Carné-Sánchez, J. Zhang, S. Ikemura, C. Kim, H. Inaba, S. Kitagawa and S. Furukawa, Chem. Sci., 2017, 8, 2381
DOI: 10.1039/C6SC04824B

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