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Issue 10, 2016
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Observing single nanoparticle events at the orifice of a nanopipet

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Abstract

Single nanoparticle (NP) events are successfully observed at the orifice of a nanopipet by blocking the ionic current with a single NP. In addition to the traditional translocation events, we observe both staircase and blip current transients by controlling the radius ratio of NPs to nanopipet or bias potential. Confocal fluorescence microscopy and finite element simulation are used to simultaneously monitor and quantitatively understand these events, respectively. The frequency of the staircase and blip events is proportional to the NP concentration, and could be used for the quantification of NPs. This study offers a new method for NP determination and single NP behavior study.

Graphical abstract: Observing single nanoparticle events at the orifice of a nanopipet

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Publication details

The article was received on 20 May 2016, accepted on 02 Jul 2016 and first published on 04 Jul 2016


Article type: Edge Article
DOI: 10.1039/C6SC02241C
Chem. Sci., 2016,7, 6365-6368
  • Open access: Creative Commons BY license
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    Observing single nanoparticle events at the orifice of a nanopipet

    T. Li, X. He, K. Zhang, K. Wang, P. Yu and L. Mao, Chem. Sci., 2016, 7, 6365
    DOI: 10.1039/C6SC02241C

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