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Issue 10, 2016
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Observing single nanoparticle events at the orifice of a nanopipet

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Abstract

Single nanoparticle (NP) events are successfully observed at the orifice of a nanopipet by blocking the ionic current with a single NP. In addition to the traditional translocation events, we observe both staircase and blip current transients by controlling the radius ratio of NPs to nanopipet or bias potential. Confocal fluorescence microscopy and finite element simulation are used to simultaneously monitor and quantitatively understand these events, respectively. The frequency of the staircase and blip events is proportional to the NP concentration, and could be used for the quantification of NPs. This study offers a new method for NP determination and single NP behavior study.

Graphical abstract: Observing single nanoparticle events at the orifice of a nanopipet

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Supplementary files

Article information


Submitted
20 May 2016
Accepted
02 Jul 2016
First published
04 Jul 2016

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2016,7, 6365-6368
Article type
Edge Article

Observing single nanoparticle events at the orifice of a nanopipet

T. Li, X. He, K. Zhang, K. Wang, P. Yu and L. Mao, Chem. Sci., 2016, 7, 6365
DOI: 10.1039/C6SC02241C

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