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Issue 10, 2015
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Pd(II)-catalyzed remote regiodivergent ortho- and meta-C–H functionalizations of phenylethylamines

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Abstract

Site selectivity control is of vital importance in the direct functionalization of inert C–H bonds. Reported here is a novel example of remote regiodivergent ortho- and meta-C–H bond functionalizations of phenylethylamine derivatives by using a novel 2-cyanobenzoyl group as the original directing functionality, where the regioselectivity was adjusted by a methylation. The potential of the method was exemplified by sequential functionalizations of both ortho- and meta-C–H bonds of a phenylethylamine derivative in a streamlined manner.

Graphical abstract: Pd(ii)-catalyzed remote regiodivergent ortho- and meta-C–H functionalizations of phenylethylamines

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Publication details

The article was received on 12 May 2015, accepted on 24 Jun 2015 and first published on 25 Jun 2015


Article type: Edge Article
DOI: 10.1039/C5SC01737H
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Chem. Sci., 2015,6, 5595-5600
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    Pd(II)-catalyzed remote regiodivergent ortho- and meta-C–H functionalizations of phenylethylamines

    S. Li, H. Ji, L. Cai and G. Li, Chem. Sci., 2015, 6, 5595
    DOI: 10.1039/C5SC01737H

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