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Issue 6, 2015
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Addressing, amplifying and switching DNAzyme functions by electrochemically-triggered release of metal ions

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Abstract

The design of artificial cells, which mimic the functions of native cells, is an ongoing scientific goal. The development of stimuli-responsive chemical systems that stimulate cascaded catalytic transformations, trigger chemical networks, and control vectorial branched transformations and dose-controlled processes, are the minimum requirements for mimicking cell functions. We have studied the electrochemical programmed release of ions from electrodes, which trigger selective DNAzyme-driven chemical reactions, cascaded reactions that self-assemble catalytic DNAzyme polymers, and the ON–OFF switching and dose-controlled operation of catalytic reactions. The addressable and potential-controlled release of Pb2+ or Ag+ ions into an electrolyte that includes a mixture of nucleic acids, results in the metal ion-guided selection of nucleic acids yielding the formation of specific DNAzymes, which stimulate orthogonal reactions or activate DNAzyme cascades.

Graphical abstract: Addressing, amplifying and switching DNAzyme functions by electrochemically-triggered release of metal ions

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Publication details

The article was received on 01 Mar 2015, accepted on 08 Apr 2015 and first published on 08 Apr 2015


Article type: Edge Article
DOI: 10.1039/C5SC00744E
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Chem. Sci., 2015,6, 3544-3549
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    Addressing, amplifying and switching DNAzyme functions by electrochemically-triggered release of metal ions

    L. Freage, A. Trifonov, R. Tel-Vered, E. Golub, F. Wang, J. S. McCaskill and I. Willner, Chem. Sci., 2015, 6, 3544
    DOI: 10.1039/C5SC00744E

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