Issue 7, 2015

Hyperpolarization of amino acid derivatives in water for biological applications

Abstract

We report on the successful synthesis and hyperpolarization of N-unprotected α-amino acid ethyl propionate esters and extensively, on an alanine derivative hyperpolarized by PHIP (4.4 ± 1.0% 13C-polarization), meeting required levels for in vivo detection. Using water as solvent increases biocompatibility and the absence of N-protection is expected to maintain biological activity.

Graphical abstract: Hyperpolarization of amino acid derivatives in water for biological applications

Supplementary files

Article information

Article type
Edge Article
Submitted
10 Feb 2015
Accepted
07 May 2015
First published
26 May 2015
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2015,6, 4261-4266

Author version available

Hyperpolarization of amino acid derivatives in water for biological applications

S. Glöggler, S. Wagner and L.-S. Bouchard, Chem. Sci., 2015, 6, 4261 DOI: 10.1039/C5SC00503E

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