Issue 4, 2015

A catalytic chiral gel microfluidic reactor assembled via dynamic covalent chemistry

Abstract

A novel dynamic covalent gel strategy is reported to immobilize an asymmetric catalyst within the channels of a microfluidic flow reactor. A layer of a catalytically active Mn–salen dynamic covalent imine gel matrix was coated onto a functionalized capillary. Mn–salen active moiety was incorporated into dynamic covalent imine gel matrix via the reaction of a chiral Mn–salen dialdehyde unit with a tetraamine linker. The catalytic activity of the capillary reactor has been demonstrated in enantioselective kinetic resolution of secondary alcohols.

Graphical abstract: A catalytic chiral gel microfluidic reactor assembled via dynamic covalent chemistry

Supplementary files

Article information

Article type
Edge Article
Submitted
27 Jan 2015
Accepted
18 Feb 2015
First published
18 Feb 2015
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2015,6, 2292-2296

A catalytic chiral gel microfluidic reactor assembled via dynamic covalent chemistry

H. Liu, J. Feng, J. Zhang, P. W. Miller, L. Chen and C. Su, Chem. Sci., 2015, 6, 2292 DOI: 10.1039/C5SC00314H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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