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Issue 6, 2014
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Pattern-based sensing of aminoglycosides with fluorescent amphiphiles

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Abstract

A mixture of two amphiphiles with fluorescent head groups can be used as a sensing ensemble for the pattern-based analysis of aminoglycoside antibiotics. In buffered aqueous solution, the amphiphiles form a dynamic mixture of micellar aggregates. In the presence of aminoglycosides, the relative amount and the composition of the micelles is modified. The re-equilibration of the system is analyte-specific, and characteristic fluorescence spectra are obtained for different aminoglycosides. Accurate differentiation in the low micromolar concentration range can be achieved by a principal component analysis of the spectral data.

Graphical abstract: Pattern-based sensing of aminoglycosides with fluorescent amphiphiles

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Submitted
11 Mar 2014
Accepted
03 Apr 2014
First published
14 Apr 2014

Chem. Sci., 2014,5, 2456-2460
Article type
Edge Article

Pattern-based sensing of aminoglycosides with fluorescent amphiphiles

Z. Köstereli, R. Scopelliti and K. Severin, Chem. Sci., 2014, 5, 2456
DOI: 10.1039/C4SC00737A

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