Issue 1, 2014
From the journal:

Chemical Science

Highly potent, chemically stable quorum sensing agonists for vibrio Cholerae†

Lark J. Perez,‡a   Theodora K. Karagounis,a   Amanda Hurley,b   Bonnie L. Basslerbc  and  Martin F. Semmelhack*a  

* Corresponding authors

a Department of Chemistry, Princeton University, Washington Road, Princeton, NJ 08544, USA
E-mail: mfshack@princeton.edu

b Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA

c Howard Hughes Medical Institute, Chevy Chase, MD 02815, USA

Abstract

In the Vibrio cholerae pathogen, initiation of bacterial quorum sensing pathways serves to suppress virulence. We describe herein a potent and chemically stable small molecule agonist of V. cholerae quorum sensing, which was identified through rational drug design based on the native quorum sensing signal. This novel agonist may serve as a useful lead compound for the control of virulence in V. cholerae.

Graphical abstract: Highly potent, chemically stable quorum sensing agonists for vibrio Cholerae

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Article information

DOI
https://doi.org/10.1039/C3SC52572D
Article type
Edge Article
Submitted
12 Sep 2013
Accepted
08 Oct 2013
First published
09 Oct 2013

Chem. Sci., 2014,5, 151-155

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Highly potent, chemically stable quorum sensing agonists for vibrio Cholerae

L. J. Perez, T. K. Karagounis, A. Hurley, B. L. Bassler and M. F. Semmelhack, Chem. Sci., 2014, 5, 151 DOI: 10.1039/C3SC52572D

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