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Issue 1, 2014
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Highly potent, chemically stable quorum sensing agonists for vibrio Cholerae

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Abstract

In the Vibrio cholerae pathogen, initiation of bacterial quorum sensing pathways serves to suppress virulence. We describe herein a potent and chemically stable small molecule agonist of V. cholerae quorum sensing, which was identified through rational drug design based on the native quorum sensing signal. This novel agonist may serve as a useful lead compound for the control of virulence in V. cholerae.

Graphical abstract: Highly potent, chemically stable quorum sensing agonists for vibrio Cholerae

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Publication details

The article was received on 12 Sep 2013, accepted on 08 Oct 2013 and first published on 09 Oct 2013


Article type: Edge Article
DOI: 10.1039/C3SC52572D
Chem. Sci., 2014,5, 151-155

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    Highly potent, chemically stable quorum sensing agonists for vibrio Cholerae

    L. J. Perez, T. K. Karagounis, A. Hurley, B. L. Bassler and M. F. Semmelhack, Chem. Sci., 2014, 5, 151
    DOI: 10.1039/C3SC52572D

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