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Issue 12, 2013
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Scalable synthesis of γ-thiolysine starting from lysine and a side by side comparison with δ-thiolysine in non-enzymatic ubiquitination

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Abstract

We developed a scalable synthesis of γ-thiolysine starting straight from lysine. The application of γ-thiolysine was compared to δ-thiolysine in the chemical synthesis of K48 and K33 linked diubiquitin conjugates. Both γ- and δ-thiolysine were found to perform equally efficiently as handles for non-enzymatic ubiquitination.

Graphical abstract: Scalable synthesis of γ-thiolysine starting from lysine and a side by side comparison with δ-thiolysine in non-enzymatic ubiquitination

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Article information


Submitted
07 Jun 2013
Accepted
11 Sep 2013
First published
18 Sep 2013

Chem. Sci., 2013,4, 4494-4498
Article type
Edge Article

Scalable synthesis of γ-thiolysine starting from lysine and a side by side comparison with δ-thiolysine in non-enzymatic ubiquitination

R. Merkx, G. de Bruin, A. Kruithof, T. van den Bergh, E. Snip, M. Lutz, F. El Oualid and H. Ovaa, Chem. Sci., 2013, 4, 4494
DOI: 10.1039/C3SC51599K

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