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Issue 9, 2013
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An enantioselective artificial metallo-hydratase

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Abstract

Direct addition of water to alkenes to generate important chiral alcohols as key motif in a variety of natural products still remains a challenge in organic chemistry. Here, we report the first enantioselective artificial metallo-hydratase, based on the transcription factor LmrR, which catalyses the conjugate addition of water to generate chiral β-hydroxy ketones with enantioselectivities up to 84% ee. A mutagenesis study revealed that an aspartic acid and a phenylalanine located in the active site play a key role in achieving efficient catalysis and high enantioselectivities.

Graphical abstract: An enantioselective artificial metallo-hydratase

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Publication details

The article was received on 23 May 2013, accepted on 26 Jun 2013 and first published on 27 Jun 2013


Article type: Edge Article
DOI: 10.1039/C3SC51449H
Chem. Sci., 2013,4, 3578-3582

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    An enantioselective artificial metallo-hydratase

    J. Bos, A. García-Herraiz and G. Roelfes, Chem. Sci., 2013, 4, 3578
    DOI: 10.1039/C3SC51449H

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